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KMID : 0357920020360060429
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Korean Journal of Pathology
2002 Volume.36 No. 6 p.429 ~ p.432
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Ipsilateral Synchronous Renal Cell Carcinoma and Transitional Cell Carcinoma: A Case Report
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Park Ji-Young
Kwak Eun-Kyung
Park Tae-In
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Abstract
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We report a synchronous renal cell carcinoma (RCC) and renal pelvic transitional cell carcinoma (TCC) in the kidney of a 74-year-old man. The kidney was without hydronephrosis. The patient was admitted to the hospital because he had intermittent gross hematuria for three years. Histologically, a section of the specimen revealed a conventional (clear cell) RCC in renal parenchyma just beneath the renal pelvis and a papillary urothelial carcinoma arising from the renal pelvis at the upper pole; the two are completely separated from one another. The tumor cells of the TCC showed an overexpression of c-MET immunohistochemical staining and more intense positive reactivity for p53 immunohistochemical staining than those of the RCC. These findings suggest that c-Met and p53 may be associated with the development of papillary TCC.
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KEYWORD
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Kidney Neoplasms, Carcinoma, Renal Cell-Carcinoma, Transitional Cell
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